Neuromuscular Junction Simulation 2.1

Neuromuscular Junction Simulation is an interactive learning and exploration tool that models how motor neurons communicate with skeletal muscle fibers. It walks users through each step of synaptic transmission—from presynaptic action potential and calcium influx to acetylcholine release, receptor activation, end-plate potentials, and excitation–contraction coupling—so you can visualize how microscopic events produce macroscopic muscle responses.

Key features:

• Real-time visualization of presynaptic spikes, calcium dynamics, vesicle docking/fusion, neurotransmitter diffusion, receptor binding, and postsynaptic responses
• Adjustable parameters, including ion concentrations, temperature, channel conductances, release probability, quantal content, receptor density, and acetylcholinesterase activity
• Pharmacology and pathology scenarios (for example: myasthenia gravis, Lambert–Eaton syndrome, botulinum toxin, curare, and anticholinesterases) to compare effects on synaptic strength and muscle activation
• Experiment builder for paired-pulse protocols, stimulus trains, facilitation/depression, and fatigue, with data export for further analysis
• Multiple modeling modes (deterministic and stochastic) with reproducible runs for classroom demonstrations or lab exercises
• Graphs and readouts, including membrane potentials, intracellular calcium, end-plate potentials, release event rasters, and quantal distributions
• Teaching aids such as preset lessons, guided prompts, and a glossary of key terms

Ideal for:

• Students and educators in physiology, neuroscience, biomedical engineering, and allied health
• Learners who prefer hands-on, visual exploration of synaptic mechanisms

What you can learn:

• How changes in cellular parameters alter synaptic transmission and muscle response
• How to interpret end-plate potentials, miniature events, and quantal analysis
• The impact of drugs and diseases on neuromuscular communication and force generation

Developer: Unknown

The most popular version of Neuromuscular Junction Simulation among our users is 2.1. The name of the program executable file is Nmj.exe.

You can check Construction Simulation INT, Junction Link Magic, Autodesk Simulation CFD Viewer and other related programs like Color Junction at the "download" section.